Adult myoclonic epilepsy: A distinct syndrome of idiopathic generalized epilepsy

被引:35
作者
Gilliam, F
Steinhoff, BJ
Bittermann, HJ
Kuzniecky, R
Faught, E
Abou-Khalil, B
机构
[1] Washington Univ, Sch Med, Epilepsy Ctr, St Louis, MO 63110 USA
[2] Univ Gottingen, Dept Clin Neurophysiol, D-3400 Gottingen, Germany
[3] Univ Alabama, Birmingham, AL USA
[4] Vanderbilt Univ, Dept Neurol, Nashville, TN USA
关键词
D O I
10.1212/WNL.55.7.1030
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors present 11 cases of idiopathic generalized epilepsy that began in adulthood at a mean age of 39 years. All patients had myoclonic jerks, five had absence seizures, and nine had infrequent generalized tonic-clonic seizures. A majority had a family history of seizures. EEG in all patients showed generalized epileptiform abnormalities, whereas neuroimaging and neurologic examination results were normal. This series appears to represent a previously undescribed idiopathic generalized epilepsy syndrome of adult myoclonic epilepsy.
引用
收藏
页码:1030 / 1033
页数:4
相关论文
共 10 条
[1]  
Berkovic S.F, 1994, EPILEPTIC SEIZURES S, P157
[2]  
*COMM CLASS TERM I, 1989, EPILEPSIA, V30, P268
[3]   Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q [J].
Elmslie, FV ;
Rees, M ;
Williamson, MP ;
Kerr, M ;
Kjeldsen, MJ ;
Pang, KA ;
Sundqvist, A ;
Friis, ML ;
Chadwick, D ;
Richens, A ;
Covanis, A ;
Santos, M ;
Arzimanoglou, A ;
Panayiotopoulos, CP ;
Curtis, D ;
Whitehouse, WP ;
Gardiner, RM .
HUMAN MOLECULAR GENETICS, 1997, 6 (08) :1329-1334
[4]   JUVENILE MYOCLONIC EPILEPSY IN UNEXPECTED AGE-GROUPS [J].
GRAM, L ;
ALVING, J ;
SAGILD, JC ;
DAM, M .
EPILEPSY RESEARCH, 1988, 2 (02) :137-140
[5]   JUVENILE MYOCLONIC EPILEPSY (JME) MAY BE LINKED TO THE BF AND HLA LOCI ON HUMAN CHROMOSOME-6 [J].
GREENBERG, DA ;
DELGADOESCUETA, AV ;
WIDELITZ, H ;
SPARKES, RS ;
TREIMAN, L ;
MALDONADO, HM ;
PARK, MS ;
TERASAKI, PI .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1988, 31 (01) :185-192
[6]   The idiopathic generalized epilepsies of adolescence with childhood and juvenile age of onset [J].
Janz, D .
EPILEPSIA, 1997, 38 (01) :4-11
[7]  
JANZ D, 1953, ARCH PSYCHIAT NERVEN, V191, P523
[8]   Genetic localization of the familial adult myoclonic epilepsy (FAME) gene to chromosome 8q24 [J].
Plaster, NM ;
Uyama, E ;
Uchino, M ;
Ikeda, T ;
Flanigan, KM ;
Kondo, I ;
Ptácek, LJ .
NEUROLOGY, 1999, 53 (06) :1180-1183
[9]   Clinical and genetic analysis of a large pedigree with juvenile myoclonic epilepsy [J].
Serratosa, JM ;
DelgadoEscueta, AV ;
Medina, MT ;
Zhang, QW ;
Iranmanesh, R ;
Sparkes, RS .
ANNALS OF NEUROLOGY, 1996, 39 (02) :187-195
[10]   Quantitative MRI in patients with idiopathic generalized epilepsy - Evidence of widespread cerebral structural changes [J].
Woermann, FG ;
Sisodiya, SM ;
Free, SL ;
Duncan, JS .
BRAIN, 1998, 121 :1661-1667