Effect of therapeutic macromolecules in spheroids

被引：41

作者：

Fracasso, G ^{[1
]}

Colombatti, M ^{[1
]}

机构：

[1] Univ Verona, Policlin Borgo Roma, Dept Pathol, Immunol Sect, I-37134 Verona, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2000年 / 36卷 / 2-3期

关键词：

spheroids; tumors; macromolecules; therapy; immunotherapy; immunotoxins;

D O I：

10.1016/S1040-8428(00)00084-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent advances in biotechnology have allowed the production of new types of macromolecular therapeutic agents (antibodies, immunotoxins, cytokines, extracellular matrix molecule (ECM) proteins, vectors) that may eventually find broad clinical applications in the treatment of human tumors and other diseases. The model of the Multicellular Tumor Spheroids (MTS) represents a valuable tool to test the therapeutic potential of these new pharmacologic agents in a 3-D context. Specific questions pertaining to the behaviour in a 3-D setting of some of the macromolecules under evaluation for in vivo applications can also be addressed in the MTS model (e.g. 'binding site barrier', role of cell-cell and cell-ECM interactions). This paper reviews the most significant contributions regarding the delivery of macromolecules to MTS, the penetration and therapeutic effects of antibodies, radiolabelled antibodies, immunotoxins and other macromolecular compounds. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：159 / 178

页数：20

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