Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue

被引：31

作者：

Hosokawa, Y ^{[1
]}

Nakanishi, T ^{[1
]}

Yamaguchi, D ^{[1
]}

Nakae, H ^{[1
]}

Matsuo, T ^{[1
]}

机构：

[1] Univ Tokushima, Sch Dent, Dept Conservat Dent, Tokushima 7708504, Japan

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2005年 / 139卷 / 03期

关键词：

CX3CR1; fractalkine; periodontal disease;

D O I：

10.1111/j.1365-2249.2005.02675.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The regulatory role of chemokines and chemokine receptors on specific leucocyte recruitment into periodontal diseased tissue is poorly characterized. We observed that leucocytes infiltrating inflamed gingival tissue expressed marked levels of CX3CR1. In periodontal diseased tissue, the expression of fractalkine and CX3CR1 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and further, fractalkine was distributed mainly on endothelial cells, as shown by immunohistochemistry. Moreover, we can detect CX3CR1-expressing cells infiltrated in periodontal diseased tissue by immunohistochemical staining. Furthermore, fractalkine production by human umbilical vein endothelial cells (HUVEC) was up-regulated by pathogen-associated molecular patterns (PAMPs), including Porphyromonas gingivalis lipopolysaccharide (LPS). Thus, these findings suggested that CX3CR1 and the corresponding chemokine, fractalkine may have an important regulatory role on specific leucocyte migration into inflamed periodontal tissue.

引用

页码：506 / 512

页数：7

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