Chronic myeloid leukemia: Proving ground for cancer stem cells

被引：24

作者：

Daley, GQ ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, Dept Biol Chem & Mol Pharmacol,Div Pediat Hematol, Boston, MA 02115 USA

来源：

CELL | 2004年 / 119卷 / 03期

关键词：

D O I：

10.1016/j.cell.2004.10.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A central question in cancer biology is whether malignancy arises in self-renewing tissue stem cells that suffer oncogene activation or in differentiated cells that acquire properties of unremitting self-renewal? In two papers, Weissman and colleagues document both mechanisms: chronic leukemia arising by mutation affecting the hematopoietic stem cell (HSC) and acute leukemia evolving from committed granulocyte-macrophage progenitors that have acquired the self-renewal machinery of HSCs.

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收藏

页码：314 / 316

页数：3

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