New kilogram-synthesis of the anti-Alzheimer drug (-)-galanthamine

被引：63

作者：

Czollner, L

Frantsits, W

Küenburg, B

Hedenig, U

Fröhlich, J

Jordis, U

机构：

[1] Vienna Univ Technol, Inst Organ Chem, A-1060 Vienna, Austria

[2] Sanochemia AG, A-2491 Neufeld, Austria

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

asymmetric synthesis; phenols; polycyclic heterocyclic compounds;

D O I：

10.1016/S0040-4039(98)00294-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise, scalable synthesis of(-)-galanthamine, a drug being used for the treatment of Alzheimer's disease, is described. The yield of the critical phenolic coupling step was optimized to 45-50%. For the reduction of the aryl bromide, air-activated LiAlH4 was used and racemic narwedine was converted to (-)-narwedine by a second order asymmetric transformation. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2087 / 2088

页数：2

共 7 条

[1] PHENOL OXIDATION AND BIOSYNTHESIS .5. SYNTHESIS OF GALANTHAMINE [J].