Is refractory epilepsy due to genetically determined resistance to antiepileptic drugs?

被引:11
作者
Pedley, TA [1 ]
Hirano, M [1 ]
机构
[1] Columbia Univ, Dept Neurol, New York, NY 10027 USA
关键词
D O I
10.1056/NEJMe030023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1480 / 1482
页数:4
相关论文
共 22 条
[1]   How long does it take for partial epilepsy to become intractable? [J].
Berg, AT ;
Langfitt, J ;
Shinnar, S ;
Vickrey, BG ;
Sperling, MR ;
Walczak, T ;
Bazil, C ;
Pacia, SV ;
Spencer, SS .
NEUROLOGY, 2003, 60 (02) :186-190
[2]   A family of drug transporters: The multidrug resistance-associated proteins [J].
Borst, P ;
Evers, R ;
Kool, M ;
Wijnholds, J .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (16) :1295-1302
[3]   Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy [J].
Dombrowski, SM ;
Desai, SY ;
Marroni, M ;
Cucullo, L ;
Goodrich, K ;
Bingaman, W ;
Mayberg, MR ;
Bengez, L ;
Janigro, D .
EPILEPSIA, 2001, 42 (12) :1501-1506
[4]   Functional polymorphisms of the human multidrug-resistance gene:: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo [J].
Hoffmeyer, S ;
Burk, O ;
von Richter, O ;
Arnold, HP ;
Brockmöller, J ;
Johne, A ;
Cascorbi, I ;
Gerloff, T ;
Roots, I ;
Eichelbaum, M ;
Brinkmann, U .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3473-3478
[5]   ABC drug transporters:: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2 [J].
Kerb, R ;
Hoffmeyer, S ;
Brinkmann, U .
PHARMACOGENOMICS, 2001, 2 (01) :51-64
[6]  
Kerb R., 2001, Pharmacogenomics Journal, V1, P204
[7]   Regional expression of multidrug resistance genes in genetically epilepsy-prone audiogenic rat brain after a single seizure [J].
Kwan, P ;
Sills, GJ ;
Butler, E ;
Gant, TW ;
Meldrum, BS ;
Brodie, MJ .
EPILEPSIA, 2002, 43 (11) :1318-1323
[8]   Role of multidrug transporters in pharmacoresistance to antiepileptic drugs [J].
Löscher, W ;
Potschka, H .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 301 (01) :7-14
[9]  
MacDonald BK, 2001, ANN NEUROL, V50, P830
[10]  
MacDonald BK, 2000, ANN NEUROL, V48, P833, DOI 10.1002/1531-8249(200012)48:6<833::AID-ANA3>3.0.CO