Intrapartum mucosal exposure to human immunodeficiency virus type 1 (HIV-1) of infants born to HIV-1-infected mothers correlates with maternal plasma virus burden

被引：21

作者：

Ait-Khaled, M

Lyall, EGH

Stainsby, C

Taylor, GP

Wright, A

Weber, JN

McClure, MO

Tudor-Williams, G

机构：

[1] Univ London Imperial Coll Sci Technol & Med, St Marys, Sch Med, Dept Paediat, London W2 1PG, England

[2] Jefferiss Res Trust Labs, Dept Genitourinary Med & Communicable Dis, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 177卷 / 04期

关键词：

D O I：

10.1086/517403

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The majority of vertical infections with human immunodeficiency virus type 1 (HIV-1) occur at or near delivery, strongly suggesting a mucosal route of transmission. The frequency and level of intrapartum mucosal exposure to HIV-1 of 22 infants born to infected mothers was investigated. Maternal plasma HIV-1 RNA and CD4 cell count were measured at delivery. Infant oropharyngeal aspirates obtained at birth were examined for HIV-1 RNA by reverse transcription-polymerase chain reaction and qualitative nucleic acid sequence-based amplification. Nine infants (41%) had detectable levels of HIV-1 RNA, 3 of which were quantifiable (mean, 3000 copies/mL). This mucosal exposure to HIV-1 during delivery did not lead to infection of any infant. Cesarian delivery did not reduce mucosal exposure to HIV-1. Mucosal exposure did not correlate with maternal CD4 cell count but did correlate with maternal plasma virus load and was reduced by antiretroviral therapy.

引用

页码：1097 / 1100

页数：4

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