Vitamin D status and incidence of tuberculosis among contacts of pulmonary tuberculosis patients

被引：20

作者：

Arnedo-Pena, A. ^{[1
,2
]}

Juan-Cerdan, J. V. ^{[3
]}

Romeu-Garcia, A. ^{[1
]}

Garcia-Ferrer, D. ^{[3
]}

Holguin-Gomez, R. ^{[4
]}

Iborra-Millet, J. ^{[3
]}

Gil-Fortuno, M. ^{[5
]}

Gomila-Sard, B. ^{[6
]}

Roach-Poblete, F. ^{[6
]}

机构：

[1] Publ Hlth Ctr, Div Epidemiol, Castellon de La Plana 12003, Spain

[2] Ctr Invest Biomed Red Epidemiol & Salud Publ, Barcelona, Spain

[3] Gen Hosp, Biochem Lab, Castellon de La Plana, Spain

[4] Hosp La Plana, Prevent Med Serv, Vila Real, Spain

[5] Hosp La Plana, Microbiol Lab, Vila Real, Spain

[6] Gen Hosp, Microbiol Lab, Castellon de La Plana, Spain

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2015年 / 19卷 / 01期

关键词：

prospective cohort study; contacts; epidemiology; LATENT TUBERCULOSIS; SKIN-TEST;

D O I：

10.5588/ijtld.14.0348

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A prospective cohort study was conducted from 2009 to 2012 to assess the relationship between serum baseline 25-hydroxivytamin D (vitamin D) status and the incidence of tuberculosis (TB) among 572 contacts of 89 pulmonary TB patients in Castellon, Spain. Three new cases of pulmonary TB occurred, with an incidence density of 3.6 per 1000 person-years. Mean vitamin D status was 13.7 ng/ml for cases and 25.7 ng/ml for non-cases. Vitamin D status showed a significant inverse association with TB incidence (adjusted HR 0.88, 95%CI 0.80-0.97). This result is in line with the hypothesis that vitamin D deficiency is associated with TB incidence.

引用

页码：65 / 69

页数：5

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