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Relationship between anxiety and serotonin in the ventral striatum

被引：70
作者：
Schwarting, RKW
Thiel, CM
Müller, CP
Huston, JP
机构：
[1] Univ Dusseldorf, Inst Physiol Psychol 1, D-40225 Dusseldorf, Germany
[2] Univ Dusseldorf, Ctr Biol & Med Res, D-40225 Dusseldorf, Germany
来源：
NEUROREPORT | 1998年 / 9卷 / 06期
关键词：
amygdala; anxiety; dopamine; emotionality; frontal cortex; hippocampus; open-field; plus-maze; serotonin; striatum;
D O I：
10.1097/00001756-199804200-00013
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
RATS were tested in an elevated plus-maze on two consecutive days. Based on the percentage of time spent in the open arms on the Ist day, they were divided into two subgroups with either low or high anxiety levels. A post-mortem neurochemical analysis showed that animals with high anxiety had lower ventral striatal tissue levels of 5-HT. No such differences were found for 5-HT in other brain areas or in dopamine and norepinephrine levels. The ventral striatal 5-HT levels correlated with plus-maze behavior on the 2nd but not Ist day. These data suggest that individual differences in ventral striatal 5-HT interact with plus-maze behavior, which may help to explain why serotonergic drugs can have inconsistent effects in this paradigm. (C) 1998 Rapid Science Ltd.
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页码：1025 / 1029
页数：5
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