TSG-6: a multifunctional protein associated with inflammation

被引:310
作者
Milner, CM [1 ]
Day, AJ [1 ]
机构
[1] MRC, Immunochem Unit, Dept Biochem, Oxford OX1 3QU, England
关键词
TSG-6; hyaluronan; inter-alpha-inhibitor; ovulation; inflammation; arthritis;
D O I
10.1242/jcs.00407
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
TSG-6 expression is upregulated in many cell types in response to a variety of proinflammatory mediators and growth factors. This protein is detected in several inflammatory disease states (e.g. rheumatoid arthritis) and in the context of inflammation-like processes, such as ovulation, and is often associated with extracellular matrix remodelling. TSG-6 has anti-inflammatory and chondroprotective effects in various models of inflammation and arthritis, which suggest that it is a component of a negative feedback loop capable of downregulating the inflammatory response. Growing evidence also indicates that TSG-6 acts as a crucial factor in ovulation by influencing the expansion of the hyaluronan-rich cumulus extracellular matrix in the preovulatory follicle. TSG-6 is a member of the Link module superfamily and binds to hyaluronan (a vital component of extracellular matrix), as well as other glycosaminoglycans, via its Link module. In addition, TSG-6 forms both covalent and non-covalent complexes with inter-alpha-inhibitor (a serine protease inhibitor present at high levels in serum) and potentiates its anti-plasmin activity.
引用
收藏
页码:1863 / 1873
页数:11
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