Enantioresolution and absolute configurations of chiral meta-substituted diphenylmethanols as determined by X-ray crystallographic and 1H NMR anisotropy methods

被引：18

作者：

Kosaka, M

Sugito, T

Kasai, Y

Kuwahara, S

Watanabe, M

Harada, N

Job, GE

Shvet, A

Pirkle, WH

机构：

[1] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan

[2] Univ Illinois, Sch Chem Sci, Urbana, IL 61801 USA

来源：

CHIRALITY | 2003年 / 15卷 / 04期

关键词：

chiral phthalic acid; diastereomeric esters; HPLC separation on silica gel; internal standard of absolute configuration; chiral derivatizing agent; 2-metboxy-2-(1-naphthyl)propionic acid; M alpha NP acid;

D O I：

10.1002/chir.10209

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

meta-Substituted diphenylmethanols were enantioresolved by the method of chiral phthalic acid yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X-ray crystallography of chiral phthalate esters and/or by the H-1 NMR anisotropy method using 2-methoxy-2-(1-naphthyl)propionic acid.

引用

页码：324 / 328

页数：5

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