Relevance of the CX3CL1/fractalkine-CX3CR1 pathway in vasculitis and vasculopathy

被引：35

作者：

Kasama, Tsuyoshi ^{[1
]}

Wakabayashi, Kuninobu ^{[1
]}

Sato, Michihito ^{[1
]}

Takahashi, Ryo ^{[1
]}

Isozaki, Takeo ^{[1
]}

机构：

[1] Showa Univ, Sch Med, Dept Med, Div Rheumatol,Shinagawa Ku, Tokyo 1428666, Japan

来源：

TRANSLATIONAL RESEARCH | 2010年 / 155卷 / 01期

关键词：

FRACTALKINE RECEPTOR CX(3)CR1; CX3C CHEMOKINE FRACTALKINE; WEGENERS-GRANULOMATOSIS; RHEUMATOID-ARTHRITIS; TNF-ALPHA; CHLAMYDIA-PNEUMONIAE; SYSTEMIC VASCULITIS; LEUKOCYTE MIGRATION; SOLUBLE FRACTALKINE; ENDOTHELIAL-CELLS;

D O I：

10.1016/j.trsl.2009.08.009

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

The clinical presentation of systemic vasculitis can vary widely and include skin disorders, neuropathy, eye symptoms, and systemic inflammation. The precise molecular mechanisms underlying this syndrome are not fully understood, but the importance of a chronic imbalance of the cytokines and chemokines involved in orchestrating inflammatory responses is now recognized. In similar fashion, atherosclerosis is now recognized to be a chronic inflammatory disease in which chemokines play important roles. In the current review, we discuss the involvement of CX3CL1, which is a unique member of the chemokine family, and its receptor, CX3CR1, in the pathogenesis of these vasculopathies. (Translational Research 2010;155:20-26)

引用

页码：20 / 26

页数：7

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