Induction of tumoricidal activity in mouse peritoneal macrophages by ginseng polysaccharide

被引：100

作者：

Wang, J. ^{[1
]}

Zuo, G. ^{[2
]}

Li, J. ^{[1
]}

Guan, T. ^{[3
]}

Li, C. ^{[4
]}

Jiang, R. ^{[1
]}

Xie, B. ^{[1
]}

Lin, X. ^{[1
]}

Li, F. ^{[1
]}

Wang, Y. ^{[1
]}

Chen, D. ^{[1
]}

机构：

[1] Chongqing Med Univ, Lab Stem Cell & Tissue Engn, Dept Histol & Embryol, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Key Lab Lab Med Diagnost, Minist Educ, Chongqing 400016, Peoples R China

[3] Chongqing Med Univ, Dept Physiol, Chongqing 400016, Peoples R China

[4] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 46卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Ginseng polysaccharide (GPS); Panax ginseng C A Meyer (Araltaceae); Mouse peritoneal macrophages; Tumoricidal activity; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; ACIDIC POLYSACCHARIDE; PANAX-GINSENG; NITRIC-OXIDE; RED GINSENG; INTERFERON-GAMMA; IFN-GAMMA; ACTIVATION; PATHWAY;

D O I：

10.1016/j.ijbiomac.2010.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This study examined the effects of ginseng polysaccharide (GPS) on mouse peritoneal macrophage (PM)mediated cytotoxicity towards K562, HL-60. or KG1 alpha cells. GPS had no direct effect on killing of tumor cells However, when mouse PMs were treated with GPS, cytotoxic activity against K562, HL-60, or KG1 alpha cells was significantly induced In addition, phagocync activity was enhanced in GPS-treated mouse PMs compared to the control. The expressions of CD68. ACP and alpha-ANE in mouse PMs were Increased by the treatment with GPS. Moreover, the levels of cytokines, including tumor necrosis factor-alpha (TNF-alpha). interleukin-1 (IL-1). IL-6 were increased and the production of nitric oxide (NO) was enhanced Taken together, these results suggest that GPS possess a potent antitumor activity by stimulating macrophage and a potentiality as an immunomodulator against diseases such as cancer. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：389 / 395

页数：7

共 31 条

[1]

RETRACTED: Activation of murine peritoneal macrophages by sulfated exopolysaccharide from marine microalgal Gyrodinium impudicum (strain KG03):: Involvement of the NF-κB and JNK pathway (Retracted article. See vol. 99, 2021) [J].