Influence of LRP5 polymorphisms on normal variation in BMD

被引：102

作者：

Koay, MA

Woon, PY

Zhang, Y

Miles, LJ

Duncan, EL

Ralston, SH

Compston, JE

Cooper, C

Keen, R

Langdahl, BL

MacLelland, A

O'Riordan, J

Pols, HA

Reid, DM

Uitterlinden, AG

Wass, JAH

Brown, MA

机构：

[1] Univ Oxford, Inst Musculoskeletal Sci, Botnar Res Ctr, Nuffield Orthopaed Ctr, Oxford OX3 7LD, England

[2] Nuffield Orthopaed Ctr, Bone Metab Unit, Oxford, England

[3] Univ Aberdeen, Sch Med, Bone Res Grp, Inst Med Sci, Aberdeen AB9 2ZD, Scotland

[4] Univ Cambridge, Sch Clin Med, Cambridge, England

[5] Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO9 4XY, Hants, England

[6] UCL, Middlesex Hosp, Dept Med, London, England

[7] Aarhus Kommune Hosp, Dept Epidemiol, DK-8000 Aarhus, Denmark

[8] Western Infirm & Associated Hosp, Dept Med & Therapeut, Glasgow, Lanark, Scotland

[9] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 10期

关键词：

osteoporosis; single nucleotide polymorphism; linkage; association; LRP5; gene;

D O I：

10.1359/JBMR.040704

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.

引用

页码：1619 / 1627

页数：9

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