Insights on antibiotic resistance of Staphylococcus aureus from its whole genome:: genomic island SCC

被引：303

作者：

Ito, T ^{[1
]}

Okuma, K ^{[1
]}

Ma, XX ^{[1
]}

Yuzawa, H ^{[1
]}

Hiramatsu, K ^{[1
]}

机构：

[1] Juntendo Univ, Dept Bacteriol, Bunkyo Ku, Tokyo 1138421, Japan

来源：

DRUG RESISTANCE UPDATES | 2003年 / 6卷 / 01期

关键词：

SCC; SCCmec; ccr; mecA; transposon;

D O I：

10.1016/S1368-7646(03)00003-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Staphylococci are ubiquitous colonizers of the skin and mucous membranes and Staphylococus aureus is the most pathogenic species. The spread of antibiotic resistance among S. aureus strains is a major concern in the treatment of staphylococcal infections. Acquisition of resistance may involve mutation of a bacterial gene on the chromosome or transfer of a resistance gene from other organisms by some form of genetic exchange (conjugation, transduction, or transformation). Completion of whole genome sequences of three methicillin-resistant S. aureus (MRSA) strains has provided us a bird's-eye view of the distribution of the mobile genetic elements in the bacterial chromosome that encode antibiotic resistance as well as pathogenicity in S. aureus. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：41 / 52

页数：12

共 56 条

[21]

Ito, 1996, J INFECT CHEMOTHER, V2, P117, DOI [DOI 10.1007/BF02351563, 10.1007/BF02351563]

[22] Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus [J].

Ito, T ;

Katayama, Y ;

Asada, K ;

Mori, N ;

Tsutsumimoto, K ;

Tiensasitorn, C ;

Hiramatsu, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (05) :1323-1336

[23] Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315 [J].

Ito, T ;

Katayama, Y ;

Hiramatsu, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) :1449-1458

[24] INSERTION OF IS2 CREATES A NOVEL AMPC PROMOTER IN ESCHERICHIA-COLI [J].

JAURIN, B ;

NORMARK, S .

CELL, 1983, 32 (03) :809-816

[25]

JEVONS MP, 1961, BRIT MED J, V1, P124, DOI 10.1136/bmj.1.5219.124-a

[26] O DEGREES AND STRONG-POLAR MUTATIONS IN GAL OPERON ARE INSERTIONS [J].

JORDAN, E ;

SAEDLER, H ;

STARLINGER, P .

MOLECULAR AND GENERAL GENETICS, 1968, 102 (04) :353-+

[27] A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus [J].

Katayama, Y ;

Ito, T ;

Hiramatsu, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1549-1555

[28] Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains:: Role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, low-level methicillin-resistant Staphylococcus haemolyticus [J].

Katayama, Y ;

Ito, T ;

Hiramatsu, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (07) :1955-1963

[29]

KATAYAMA Y, 2003, IN PRESS J BACTERIOL

[30] Eagle-type methicillin resistance:: New phenotype of high methicillin resistance under mec regulator gene control [J].

Kondo, N ;

Kuwahara-Arai, K ;

Kuroda-Murakami, H ;

Tateda-Suzuki, E ;

Hiramatsu, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (03) :815-824

← 1 2 3 4 5 6 →