The role of the PTEN gene in malignant gliomas

被引：16

作者：

Alexiou, George A. ^{[1
]}

Voulgaris, Spyridon ^{[1
]}

机构：

[1] Univ Hosp Ioannina, Dept Neurosurg, Ioannina, Greece

来源：

NEUROLOGIA I NEUROCHIRURGIA POLSKA | 2010年 / 44卷 / 01期

关键词：

PTEN; AKT; glioma; HYPOXIA-INDUCIBLE FACTOR; TUMOR-INDUCED ANGIOGENESIS; MAJOR VAULT PROTEIN; G(1) GROWTH ARREST; NUCLEAR-LOCALIZATION; GLIOBLASTOMA-MULTIFORME; PROSTATE-CANCER; CELL-MIGRATION; IN-VIVO; PHOSPHATASE-ACTIVITY;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.

引用

页码：80 / 86

页数：7

共 78 条

[1]

Regulation of glioblastoma cell invasion by PKCι and RhoB [J].

Baldwin, R. M. ;

Parolin, D. A. E. ;

Lorimer, I. A. J. .

ONCOGENE, 2008, 27 (25) :3587-3595

[2]

Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies [J].

Beckner, ME ;

Chen, X ;

An, JY ;

Day, BW ;

Pollack, IF .

LABORATORY INVESTIGATION, 2005, 85 (03) :316-327

[3]

PTEN, more than the AKT pathway [J].

Blanco-Aparicio, Carmen ;

Renner, Oliver ;

Leal, Juan F. M. ;

Carnero, Amancio .

CARCINOGENESIS, 2007, 28 (07) :1379-1386

[4]

Factors influencing survival in high-grade gliomas [J].

Buckner, JC .

SEMINARS IN ONCOLOGY, 2003, 30 (06) :10-14

[5]

Mechanisms of Disease: the PI3K-Akt-PTEN signaling node - an intercept point for the control of angiogenesis in brain tumors [J].

Castellino, Robert C. ;

Durden, Donald L. .

NATURE CLINICAL PRACTICE NEUROLOGY, 2007, 3 (12) :682-693

[6]

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression [J].

Chang, Chun-Ju ;

Mulholland, David J. ;

Valamehr, Bahram ;

Mosessian, Sherly ;

Sellers, William R. ;

Wu, Hong .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (10) :3281-3289

[7]

Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1 [J].

Chappell, WH ;

Green, TD ;

Spengeman, JD ;

McCubrey, JA ;

Akula, SM ;

Bertrand, FE .

CELL CYCLE, 2005, 4 (10) :1389-1395

[8]

Cheney IW, 1998, CANCER RES, V58, P2331

[9]

Cheyney IW, 1999, CANCER RES, V59, P2318

[10]

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein [J].

Chung, JH ;

Ginn-Pease, ME ;

Eng, C .

CANCER RESEARCH, 2005, 65 (10) :4108-4116

← 1 2 3 4 5 6 7 8 →