Recent advances in association studies of osteoarthritis susceptibility genes

被引：18

作者：

Dai, Jin ^{[1
]}

Ikegawa, Shiro ^{[1
]}

机构：

[1] RIKEN, Ctr Genom Med, Lab Bone & Joint Dis, Minato Ku, Tokyo 1088639, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2010年 / 55卷 / 02期

关键词：

association study; DVWA; GDF5; GWAS; susceptibility gene; osteoarthritis; CORE PROMOTER POLYMORPHISM; GENOME-WIDE ASSOCIATION; ACID REPEAT POLYMORPHISM; KNEE-OSTEOARTHRITIS; HIP OSTEOARTHRITIS; HAND OSTEOARTHRITIS; ARTICULAR-CARTILAGE; COMMON VARIANTS; GDF5; ASPORIN;

D O I：

10.1038/jhg.2009.137

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Osteoarthritis (OA) is a polygenic disease with a definite genetic component, and recent advances in genome research have enabled us to investigate OA susceptibility genes. Several research groups, including ours, have reported the identification of OA susceptibility genes, mainly using candidate gene association studies. However, we are now entering the era of genome-wide association studies (GWAS). Here, we review recent progress in the study of susceptibility genes for OA, focusing in particular on GWAS and large-scale replication studies. Journal of Human Genetics (2010) 55, 77-80; doi: 10.1038/jhg.2009.137; published online 15 January 2010

引用

页码：77 / 80

页数：4

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