GM1 Ganglioside: Past Studies and Future Potential

被引：124

作者：

Aureli, Massimo ^{[1
]}

Mauri, Laura ^{[1
]}

Ciampa, Maria Grazia ^{[1
]}

Prinetti, Alessandro ^{[1
]}

Toffano, Gino ^{[2
]}

Secchieri, Cynthia ^{[2
]}

Sonnino, Sandro ^{[1
]}

机构：

[1] Univ Milan, Dept Med Biotechnol & Translat Med, Via Fratelli Cervi 93, I-20090 Milan, Italy

[2] FIDIA Farmaceut, Padua, Italy

来源：

MOLECULAR NEUROBIOLOGY | 2016年 / 53卷 / 03期

关键词：

GM1; GM1 Chemistry and Physico-chemistry; GM1 and Cholera toxin; Cellular organization of GM1; Neurotrophic and neuroprotective properties of GM1; GM1 and the neurodegenerative diseases; GM1 and GBS; AMYLOID BETA-PROTEIN; GUILLAIN-BARRE-SYNDROME; PERFORMANCE LIQUID-CHROMATOGRAPHY; N-GLYCOLYLNEURAMINIC-ACID; CHAIN BASE COMPOSITION; LOCAL HEALTH DISTRICT; RAFT-LIKE MEMBRANES; NERVE GROWTH-FACTOR; CHOLERA-TOXIN; LIPID RAFTS;

D O I：

10.1007/s12035-015-9136-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Gangliosides (sialic acid-containing glycosphingolipids) are abundant in neurons of all animal species and play important roles in many cell physiological processes, including differentiation, memory control, cell signaling, neuronal protection, neuronal recovery, and apoptosis. Gangliosides also function as anchors or entry points for various toxins, bacteria, viruses, and autoantibodies. GM1, a ganglioside component of mammalian brains, is present mainly in neurons. GM1 is one of the best studied gangliosides, and our understanding of its properties is extensive. Simple and rapid procedures are available for preparation of GM1 as a natural compound on a large scale, or as a derivative containing an isotopic radionuclide or a specific probe. Great research interest in the properties of GM1 arose from the discovery in the early 1970s of its role as receptor for the bacterial toxin responsible for cholera pathogenesis.

引用

页码：1824 / 1842

页数：19

共 233 条

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