SOR1, a gene required for photosensitizer and singlet oxygen resistance in Cercospora fungi, is highly conserved in divergent organisms

被引：93

作者：

Ehrenshaft, M ^{[1
]}

Jenns, AE ^{[1
]}

Chung, KR ^{[1
]}

Daub, ME ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Plant Pathol, Raleigh, NC 27695 USA

来源：

MOLECULAR CELL | 1998年 / 1卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1097-2765(00)80060-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Filamentous Cercospora fungi are resistant to photosensitizing compounds that generate singlet oxygen. C. nicotianae photosensitizer-sensitive mutants were restored to full resistance by transformation with SOR1 (Singlet Oxygen Resistance 1), a gene recovered from a wild-type genomic library. SOR1 null mutants generated via targeted gene replacement confirmed the requirement for SOR1 in photosensitizer resistance. SOR1 RNA is present throughout the growth cycle. Although resistance to singlet oxygen is rare in biological systems, SOR1, a gene with demonstrated activity against singlet-oxygen-generating photosensitizers, is highly conserved in organisms from widely diverse taxa. The characterization of SOR1 provides an additional phenotype to this large group of evolutionarily conserved genes.

引用

页码：603 / 609

页数：7

共 39 条

[1] ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
[2] ARGOS P, 1986, METHOD ENZYMOL, V130, P185
[3] CELLULAR-RESISTANCE IN RICE TO CERCOSPORIN, A TOXIN OF CERCOSPORA
BATCHVAROVA, RB
REDDY, VS
BENNETT, J
[J]. PHYTOPATHOLOGY, 1992, 82 (06) : 642 - 646
[4] Bellus D., 1979, ADV PHOTOCHEM, V11, P105
[5] A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family
Braun, EL
Fuge, EK
Padilla, PA
WernerWashburne, M
[J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (23) : 6865 - 6872
[6] METHODS AND ALGORITHMS FOR STATISTICAL-ANALYSIS OF PROTEIN SEQUENCES
BRENDEL, V
BUCHER, P
NOURBAKHSH, IR
BLAISDELL, BE
KARLIN, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) : 2002 - 2006
[7] Chung KR, 1996, GENETICS, V142, P259
[8] DAUB ME, 1982, PHYTOPATHOLOGY, V72, P370, DOI 10.1094/Phyto-72-370
[9] DAUB ME, 1993, PHYSIOL PLANTARUM, V89, P227, DOI 10.1111/j.1399-3054.1993.tb01810.x
[10] RESISTANCE OF FUNGI TO THE PHOTOSENSITIZING TOXIN, CERCOSPORIN
DAUB, ME
[J]. PHYTOPATHOLOGY, 1987, 77 (11) : 1515 - 1520

← 1 2 3 4 →