Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients

被引：15

作者：

Costa, P ^{[1
]}

Rusconi, S

Fogli, M

Mavilio, D

Murdaca, G

Puppo, F

Mingari, MC

Galli, M

Moretta, L

De Maria, A

机构：

[1] Univ Genoa, Dipartimento Med Interna, Genoa, Italy

[2] Univ Genoa, Dipartimento Oncol Biol & Genet, Genoa, Italy

[3] Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy

[4] Univ Milan, Ist Malattie Infett & Trop, Milan, Italy

[5] Ist Sci G Gaslini, Genoa, Italy

[6] Ist Nazl Ric Canc, I-16132 Genoa, Italy

[7] Ctr Eccellenza Ric Biomed, Genoa, Italy

来源：

AIDS | 2003年 / 17卷 / 02期

关键词：

D O I：

10.1097/00002030-200301240-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mononuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients.

引用

页码：257 / 260

页数：4

共 18 条

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