Effect of Fluvastatin on Progression of Coronary Atherosclerotic Plaque Evaluated by Virtual Histology Intravascular Ultrasound

被引：105

作者：

Nasu, Kenya ^{[1
]}

Tsuchikane, Etsuo ^{[1
]}

Katoh, Osamu ^{[1
]}

Tanaka, Nobuyoshi ^{[1
]}

Kimura, Masashi ^{[1
]}

Ehara, Mariko ^{[1
]}

Kinoshita, Yoshihisa ^{[1
]}

Matsubara, Tetsuo ^{[1
]}

Matsuo, Hitoshi ^{[1
]}

Asakura, Kciko ^{[1
]}

Asakura, Yasushi ^{[1
]}

Terashima, Mitsuyasu ^{[1
]}

Takayama, Tadateru ^{[2
]}

Honye, Junko ^{[2
]}

Hirayama, Atsushi ^{[2
]}

Saito, Satoshi ^{[2
]}

Suzuki, Takahiko ^{[1
]}

机构：

[1] Toyohashi Heart Ctr, Dept Cardiol, Toyohashi, Aichi 4418530, Japan

[2] Nihon Univ Itabashi Hosp, Dept Cardiol, Tokyo, Japan

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2009年 / 2卷 / 07期

关键词：

atherosclerosis; imaging; lipids; lipoprotein; plaque; C-REACTIVE PROTEIN; LIPID-LOWERING THERAPY; STATIN THERAPY; CHOLESTEROL LEVELS; ARTERY-DISEASE; REGRESSION; ADIPONECTIN; PRAVASTATIN; COMPONENTS; MORPHOLOGY;

D O I：

10.1016/j.jcin.2009.04.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives The aim of this study was to evaluate the effect of treatment with statins on the progression of coronary atherosclerotic plaques of a nonculprit vessel by serial volumetric virtual histology (VH) intravascular ultrasound (IVUS). Background Recent clinical trials have demonstrated a reduction of atherosclerotic plaque, yet whether statin therapy affects the change in components of plaque remains unknown. Methods This study was a nonrandomized and nonblinded design. Eighty patients with stable angina pectoris were divided into either the fluvastatin group (n = 40) or the control group (n = 40) according to their total or low-density lipoprotein (LDL) cholesterol level. The volume of each plaque component (dense calcium, fibrous tissue, fibro-fatty, or necrotic core) was evaluated at baseline and at 12-month follow-up. Results The LDL cholesterol and high-sensitivity C-reactive protein (hsCRP) levels in the fluvastatin group were significantly decreased at time of follow-up. In VH IVUS findings, fibro-fatty volume was significantly decreased (baseline 80.1 +/- 57.9 mm(3) vs. follow-up 32.5 +/- 27.7 mm(3), p < 0.0001) and fibrous tissue volume was increased (baseline 146.5 +/- 85.6 mm(3) vs. follow-up 163.3 +/- 94.5 mm(3), p < 0.0001) in the fluvastatin group. In the control group, the volumes of all plaque components without fibrous tissue were significantly increased. Change in fibro-fatty volume has a significant correlation with a change in LDL cholesterol level (R = 0.703, p < 0.0001) and change in hsCRP level (R = 0.357, p = 0.006). Conclusions One-year lipid-lowering therapy by fluvastatin showed significant regression of plaque volume and alterations in atherosclerotic plaque composition with a significant reduction of fibro-fatty volume. (J Am Coll Cardiol Intv 2009;2:689-96) (C) 2009 by the American College of Cardiology Foundation

引用

页码：689 / 696

页数：8

共 28 条

[1] Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma - A potential mechanism of lesion stabilization [J].

Aikawa, M ;

Rabkin, E ;

Okada, Y ;

Voglic, SJ ;

Clinton, SK ;

Brinckerhoff, CE ;

Sukhova, GK ;

Libby, P .

CIRCULATION, 1998, 97 (24) :2433-2444

[2] ARTERIAL FIBROUS PROTEINS IN CYNOMOLGUS MONKEYS AFTER ATHEROGENIC AND REGRESSION DIETS [J].

ARMSTRONG, ML ;

MEGAN, MB .

CIRCULATION RESEARCH, 1975, 36 (02) :256-261

[3]

Bellosta S, 2000, DIABETES CARE, V23, pB72

[4] Possible contribution of C-reactive protein within coronary plaque to increasing its own plasma levels across coronary circulation [J].

Ishikawa, T ;

Imamura, T ;

Hatakeyama, K ;

Date, H ;

Nagoshi, T ;

Kawamoto, R ;

Matsuyama, A ;

Asada, Y ;

Eto, T .

AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (05) :611-614

[5] Interaction of oxidative stress and inflammatory response in coronary plaque instability - Important role of C-reactive protein [J].

Kobayashi, S ;

Inoue, N ;

Ohashi, Y ;

Terashima, M ;

Matsui, K ;

Mori, T ;

Fujita, H ;

Awano, K ;

Kobayashi, K ;

Azumi, H ;

Ejiri, J ;

Hirata, K ;

Kawashima, S ;

Hayashi, Y ;

Yokozaki, H ;

Itoh, H ;

Yokoyama, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (08) :1398-1404

[6] Densitometric quantitative analysis of intracoronary ultrasound images: Anatomopathological correlation [J].

Londero, HF ;

Laguens, R ;

Telayna, JM ;

Gonzalez, P ;

delaSerna, F ;

Wisner, JN ;

Mendiz, OA .

INTERNATIONAL JOURNAL OF CARDIAC IMAGING, 1997, 13 (02) :125-132

[7] Pharmacologic plaque passivation for the reduction of recurrent cardiac events in acute coronary syndromes [J].

Monroe, VS ;

Kerensky, RA ;

Rivera, E ;

Smith, KM ;

Pepine, CJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (04) :23S-30S

[8] Coronary plaque classification with intravascular ultrasound radiofrequency data analysis [J].

Nair, A ;

Kuban, BD ;

Tuzcu, EM ;

Schoenhagen, P ;

Nissen, SE ;

Vince, DG .

CIRCULATION, 2002, 106 (17) :2200-2206

[9] Assessing spectral algorithms to predict atherosclerotic plaque composition with normalized and raw intravascular ultrasound data [J].

Nair, A ;

Kuban, BD ;

Obuchowski, N ;

Vince, DG .

ULTRASOUND IN MEDICINE AND BIOLOGY, 2001, 27 (10) :1319-1331

[10] Accuracy of in vivo coronary plaque morphology assessment - A validation study of in vivo virtual histology compared with in vitro histopathology [J].

Nasu, Kenya ;

Tsuchikane, Etsuo ;

Katoh, Osamu ;

Vince, D. Geoffrey ;

Virmani, Renu ;

Surmely, Jean-Francois ;

Murata, Akira ;

Takeda, Yoshihiro ;

Ito, Tatsuya ;

Ehara, Mariko ;

Matsubara, Tetsuo ;

Terashima, Mitsuyasu ;

Suzuki, Takahiko .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (12) :2405-2412

← 1 2 3 →