Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis

被引:56
作者
van den Hout, WB [1 ]
de Jong, Z [1 ]
Munneke, M [1 ]
Hazes, JMW [1 ]
Breedveld, FC [1 ]
Vlieland, TPMV [1 ]
机构
[1] Leiden Univ, Ctr Med, Dept Med Decis Making J10 S, NL-2300 RC Leiden, Netherlands
来源
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH | 2005年 / 53卷 / 01期
关键词
cost-utility analysis; cost-effectiveness analysis; economic evaluation; physical therapy; exercise classes; rheumatoid arthritis;
D O I
10.1002/art.20903
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To estimate the cost utility and cost effectiveness of long-term, high-intensity exercise classes compared with usual care in rheumatoid arthritis (RA) patients. Methods. RA patients (n = 300) were randomly assigned to either exercise classes or UC; followup lasted for 2 years. Outcome measures were quality-adjusted life years (QALYs) according to the EuroQol (EQ-5D), Short Form 6D (SF-6D), and a transformed visual analog scale (VAS) rating personal health; functional ability according to the Health Assessment Questionnaire (HAQ) and McMaster Toronto Arthritis Patient Preference Interview (MACTAR); and societal costs. Results. QALYs in both randomization groups were similar according to the EQ-5D and SF-6D, but were in favor of usual care according to the VAS (annual difference 0.037 QALY; 95% confidence interval [95% CI] 0.002, 0.069). Functional ability was similar according to the HAQ, but in favor of the exercise classes according to the MACTAR (annual difference 2.9 QALY; 95% CI 0.9, 4.9). Annual medical costs of the exercise program were estimated at euro780 per participating patient (euro1 approximate to $1.05). The increase per patient in total medical costs of physical therapy was estimated at euro 430 (95% CI euro 318, 577), and the a increase in total societal costs at euro 602 (95% CI euro-490, 1,664). For societal willingness-to-pay equal to euro 50,000 per QALY. usual care had better cost utility than exercise classes, and significantly so according to the VAS. Conclusion. From a societal perspective and without taking possible preventive health effects into account, long-term, high-intensity exercise classes provide insufficient improvement in the valuation of health to justify the additional costs.
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页码:39 / 47
页数:9
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