Synthesis of ionones and carvone analogues: olfactory properties and preliminary toxicity assays

被引：11

作者：

Anzaldi, M

Sottofattori, E

Dusatti, F

Ferro, M

Pani, M

Balbi, A

机构：

[1] Univ Genoa, Dipartimento Sci Farmaceut, I-16132 Genoa, Italy

[2] Dipartimento Med Sperimentale, Sez Patol Gen, I-16132 Genoa, Italy

[3] Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 35卷 / 09期

关键词：

ionone analogues; carvone analogues; odoriferous substances; aldehydes; cytotoxicity; Vilsmeier reaction;

D O I：

10.1016/S0223-5234(00)00181-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Vilsmeier reagents react with alpha/beta-ionones and carvone to produce aldehydes 7-11 in a one-step procedure. The indene derivative 11, which came from the double iminoalkylation of carvone and ring closure with the elimination of dimethylamine, was practically odourless, while all the others had peculiar odours which were very different from the starting material. The cytotoxicity data of 9 and 10, which are the most promising potential perfume ingredients, are also reported. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：797 / 803

页数：7

共 15 条

[1] Synthesis and antimicrobial activity of heterocyclic ionone-like derivatives [J].