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Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis

被引：72
作者：
Kawamura-Sato, K
Iinuma, Y
Hasegawa, T
Horii, T
Yamashino, T
Ohta, M
机构：
[1] Nagoya Univ, Grad Sch Med, Dept Bacteriol, Showa Ku, Aichi 4668550, Japan
[2] Nagoya Univ, Grad Sch Med, Dept Clin Lab Med, Showa Ku, Aichi 4668550, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期
关键词：
D O I：
10.1128/AAC.44.10.2869-2872.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In the present study we showed by molecular analysis that the inhibition of motility by macrolides in Proteus mirabilis and Pseudomonas aeruginosa was well correlated with the loss of the expression of flagellin. Erythromycin, clarithromycin, and azithromycin at subinhibitory concentrations (sub-MICs) suppressed the expression of flagellin dose dependently. Azithromycin had the strongest inhibitory effect on the expression of P. aeruginosa flagellin, whereas 16-membered rokitamycin had only a weak inhibitory effect. These results indicate the potential effectiveness of sub-MICs of erythromycin, clarithromycin, and azithromycin for the treatment of patients with P. mirabilis and P. aeruginosa infections.
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收藏
页码：2869 / 2872
页数：4
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