Microwave-assisted, regioselective, petasis olefination of unsymmetrical oxalates. Formation of pyruvate-based enol ethers and enamines

被引：13

作者：

Cook, MJ ^{[1
]}

Fleming, DW ^{[1
]}

Gallagher, T ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 02期

关键词：

petasis reagent; olefination; pyruvates; enamines; enol ethers;

D O I：

10.1016/j.tetlet.2004.11.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Petasis olefination Of unsymmetrical oxalates and oxalate monoesters/monoamides (tert-BuO2CC(O)X. where X = OR, NR2) is highly regioselective and provides pyruvate-based enol ether and enamine derivatives. The olefination steep occurs under conventional thermal conditions, but is dramatically iniproved-shorter reaction tinies and higher vields-wheen proinowed by microwave irradiation. (C) 2004 Elsevier Ltd. All rialits reserved.

引用

页码：297 / 300

页数：4

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