Microwave-assisted, regioselective, petasis olefination of unsymmetrical oxalates. Formation of pyruvate-based enol ethers and enamines

被引:13
作者
Cook, MJ [1 ]
Fleming, DW [1 ]
Gallagher, T [1 ]
机构
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
关键词
petasis reagent; olefination; pyruvates; enamines; enol ethers;
D O I
10.1016/j.tetlet.2004.11.070
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The Petasis olefination Of unsymmetrical oxalates and oxalate monoesters/monoamides (tert-BuO2CC(O)X. where X = OR, NR2) is highly regioselective and provides pyruvate-based enol ether and enamine derivatives. The olefination steep occurs under conventional thermal conditions, but is dramatically iniproved-shorter reaction tinies and higher vields-wheen proinowed by microwave irradiation. (C) 2004 Elsevier Ltd. All rialits reserved.
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页码:297 / 300
页数:4
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