Granule cell dispersion is correlated with early epileptic events in human temporal lobe epilepsy

被引：60

作者：

Lurton, D

El Bahh, B

Sundstrom, L

Rougier, A

机构：

[1] Univ Bordeaux 2, Lab Neurobiol & Neuroimagerie Expt, F-33076 Bordeaux, France

[2] Univ Southampton, Dept Clin Neurol Sci, Southampton SO16 6YD, Hants, England

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1998年 / 154卷 / 02期

关键词：

epilepsy; hippocampus; granule cells; morphometric analysis; dispersion;

D O I：

10.1016/S0022-510X(97)00220-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Granule cell dispersion (GCD) into the dentate gyrus (DG) molecular layer was observed in hippocampal specimens in 10 out of 22 cases of human non-lesional temporal lobe epilepsy (TLE) and was associated with hippocampal sclerosis (HS). The presence of GCD was significantly linked to events of epileptic nature arising during the first 4 years of life but not with the durations of epilepsy, nor the number of seizures. Dispersion could be induced by seizure-linked structural plasticity occurring during a specific early permissive period. (C) 1998 Elsevier Science B.V.

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收藏

页码：133 / 136

页数：4

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