Emerging roles of Wnts in the adult nervous system

被引：562

作者：

Inestrosa, Nibaldo C. ^{[1
]}

Arenas, Ernest ^{[2
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Regulac Celular & Patol Joaquin V Luco CRCP, Ctr Envejecimiento & Regenerac CARE,MIFAB, Santiago, Chile

[2] Karolinska Inst, Ctr Regenerat Med & Dev Biol, Mol Neurobiol Lab, MBB, S-17177 Stockholm, Sweden

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 02期

基金：

瑞典研究理事会;

关键词：

NEURAL STEM-CELLS; ADENOMATOUS-POLYPOSIS-COLI; BETA-CATENIN; ALZHEIMERS-DISEASE; SIGNALING PROMOTES; PROGENITOR CELLS; DENTATE GYRUS; A-BETA; INT-1; PROTOONCOGENE; KINASE-I;

D O I：

10.1038/nrn2755

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The roles of the Wnt signalling pathway in several developmental processes, including synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt signalling components in the mature mammalian CNS suggests that this pathway might also play a part in synaptic maintenance and function. In fact, Wnts have a crucial role in synaptic physiology, as they modulate the synaptic vesicle cycle, the trafficking of neurotransmitter receptors and the interaction of these receptors with scaffold proteins in postsynaptic regions. In addition, Wnts participate in adult neurogenesis and protect excitatory synaptic terminals from amyloid-beta oligomer toxicity. Here, the latest insights into the function of Wnt signalling in the adult nervous system and therapeutic opportunities for neurodegenerative diseases such as Alzheimer's and Parkinson's disease are discussed.

引用

收藏

页码：77 / 86

页数：10

相关论文

共 129 条

[1]

NMDA-receptor activation induces calpain-mediated β-catenin cleavages for triggering gene expression [J].

Abe, Kentaro ;

Takeichi, Masatoshi .

NEURON, 2007, 53 (03) :387-397

[2]

β-Catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone [J].

Adachi, Kazuhide ;

Mirzadeh, Zaman ;

Sakaguchi, Masanori ;

Yamashita, Toru ;

Nikolcheva, Tania ;

Gotoh, Yukiko ;

Peltz, Gary ;

Gong, Leyi ;

Kawase, Takeshi ;

Alvarez-Buylla, Arturo ;

Okano, Hideyuki ;

Sawamoto, Kazunobu .

STEM CELLS, 2007, 25 (11) :2827-2836

[3]

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release [J].

Ahmad-Annuar, Azlina ;

Ciani, Lorenza ;

Simeonidis, Iordanis ;

Herreros, Judit ;

Ben Fredj, Naila ;

Rosso, Silvana B. ;

Hall, Anita ;

Brickley, Stephen ;

Salinas, Patricia C. .

JOURNAL OF CELL BIOLOGY, 2006, 174 (01) :127-139

[4]

For the long run: Maintaining germinal niches in the adult brain [J].

Alvarez-Buylla, A ;

Lim, DA .

NEURON, 2004, 41 (05) :683-686

[5]

Anderson CW, 2008, J HOMEL SECUR EMERG, V5

[6]

Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity [J].

Arikkath, Jyothi ;

Reichardt, Louis F. .

TRENDS IN NEUROSCIENCES, 2008, 31 (09) :487-494

[7]

Role of β-catenin in synaptic vesicle localization and presynaptic assembly [J].

Bamji, SX ;

Shimazu, K ;

Kimes, N ;

Huelsken, J ;

Birchmeier, W ;

Lu, B ;

Reichardt, LF .

NEURON, 2003, 40 (04) :719-731

[8]

A Homozygous Mutation in Human PRICKLE1 Causes an Autosomal-Recessive Progressive Myoclonus Epilepsy-Ataxia Syndrome [J].

Bassuk, Alexander G. ;

Wallace, Robyn H. ;

Buhr, Aimee ;

Buller, Andrew R. ;

Afawi, Zaid ;

Shimojo, Masahito ;

Miyata, Shingo ;

Chen, Shan ;

Gonzalez-Alegre, Pedro ;

Griesbach, Hilary L. ;

Wu, Shu ;

Nashelsky, Marcus ;

Vladar, Eszter K. ;

Antic, Dragana ;

Ferguson, Polly J. ;

Cirak, Sebahattin ;

Voit, Thomas ;

Scott, Matthew P. ;

Axelrod, Jeffrey D. ;

Gurnett, Christina ;

Daoud, Azhar S. ;

Kivity, Sara ;

Neufeld, Miriam Y. ;

Mazarib, Aziz ;

Straussberg, Rachel ;

Walid, Simri ;

Korczyn, Amos D. ;

Slusarski, Diane C. ;

Berkovic, Samuel F. ;

El-Shanti, Hatem I. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 83 (05) :572-581

[9]

Is α-T catenin (VR22) an Alzheimer's disease risk gene? [J].

Bertram, Lars ;

Mullin, Kristina ;

Parkinson, Michele ;

Hsiao, Monica ;

Moscarillo, Thomas J. ;

Wagner, Steven L. ;

Becker, K. David ;

Velicelebi, Gonul ;

Blacker, Deborah ;

Tanzi, Rudolph E. .

JOURNAL OF MEDICAL GENETICS, 2007, 44 (01)

[10]

Wnt signaling in Alzheimer's disease: Up or down, that is the question [J].

Boonen, Rick A. C. M. ;

van Tijn, Paula ;

Zivkovic, Danica .

AGEING RESEARCH REVIEWS, 2009, 8 (02) :71-82

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