Inducible gene expression in mammalian cells and transgenic mice

被引：92

作者：

Saez, E

No, D

West, A

Evans, RM

机构：

[1] Howard Hughes Medical Institute, Gene Expression Lab., Salk Institute, San Diego, CA 92037

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(97)80037-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in biomedicine have accentuated the need to develop methods to deliberately modulate gene activity. In addition to improved versions of the system based on components of the tetracycline resistance operon, several strategies have recently emerged to control gene function at the transcriptional level. Particularly promising are approaches based on non-mammalian steroid hormones, and on small molecules that bind immunophilins.

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收藏

页码：608 / 616

页数：9

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