Performance of the OraQuick rapid antibody test for diagnosis of human immunodeficiency virus type 1 infection in patients with various levels of exposure to highly active antiretroviral therapy

被引:80
作者
O'Connell, RJ
Merritt, TM
Malia, JA
VanCott, TC
Dolan, MJ
Zahwa, H
Bradley, WP
Branson, BM
Michael, NL
De Witt, CC
机构
[1] Wilford Hall USAF Med Ctr, Dept Infect Dis, Lackland AFB, TX 78236 USA
[2] Walter Reed Army Med Ctr, Div Retrovirol, Rockville, MD 20850 USA
[3] Henry M Jackson Fdn, Rockville, MD 20850 USA
[4] Ctr Dis Control & Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA
关键词
D O I
10.1128/JCM.41.5.2153-2155.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
With oral mucosal transudate and serum samples from 101 human immunodeficiency virus type 1 (HIV-1)-infected subjects and 100 HIV-1-negative volunteers, the OraQuick HIV-1 test demonstrated 100% specificity and 96% sensitivity. Four false-negative subjects, who were characterized by early initiation of effective antiretroviral therapy, demonstrated waning serum anti-gp41 titers and Western blot band intensities.
引用
收藏
页码:2153 / 2155
页数:3
相关论文
共 15 条
[1]  
Bakari JP, 2000, ANN NY ACAD SCI, V918, P64
[2]  
*CDCP, 2001, MMWR-MORBID MORTAL W, V50, P538
[3]  
Centers for Disease Control and Prevention (CDC), 1998, MMWR Morb Mortal Wkly Rep, V47, P211
[4]   Analysis of genetic variability within the immunodominant epitopes of envelope gp41 from human immunodeficiency virus type 1 (HIV-1) group M and its impact on HIV-1 antibody detection [J].
Dorn, J ;
Masciotra, S ;
Yang, CF ;
Downing, R ;
Biryahwaho, B ;
Mastro, TD ;
Nkengasong, J ;
Pieniazek, D ;
Rayfield, MA ;
Hu, DJ ;
Lal, RB .
JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (02) :773-780
[5]  
Giles RE, 1999, J MED VIROL, V59, P104, DOI 10.1002/(SICI)1096-9071(199909)59:1&lt
[6]  
104::AID-JMV17&gt
[7]  
3.0.CO
[8]  
2-U
[9]   Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus [J].
Henderson, DK .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (10) :931-936
[10]   Selective increases in HIV-specific neutralizing antibody and partial reconstitution of cellular immune responses during prolonged, successful drug therapy of HIV infection [J].
Kim, JH ;
Mascola, JR ;
Ratto-Kim, S ;
VanCott, TC ;
Loomis-Price, L ;
Cox, JH ;
Michael, NL ;
Jagodzinski, L ;
Hawkes, C ;
Mayers, D ;
Gilliam, BL ;
Birx, DC ;
Robb, ML .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2001, 17 (11) :1021-1034