A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging

被引:903
作者
McKiernan, KA [1 ]
Kaufman, JN [1 ]
Kucera-Thompson, J [1 ]
Binder, JR [1 ]
机构
[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA
关键词
D O I
10.1162/089892903321593117
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Task-induced deactivation (TID) refers to a regional decrease in blood flow during an active task relative to a "resting" or "passive" baseline. We tested the hypothesis that TID results from a reallocation of Processing resources by parametrically manipulating task difficulty within three factors : target discriminability, stimulus presentation rate, and short-term memory load. Subjects performed all auditory target detection task during functional magnetic resonance imaging (fMRI), responding to a single target tone or, in the short-term memory load conditions, to target sequences. Seven task conditions (a common version and two additional levels for each of the three factors) were each alternated with "rest" ill a block design. Analysis of covariance identified brain regions in which TID occurred. Analyses of variance identified seven regions (left anterior cingulate/superior frontal gyrus, left middle frontal gyrus, right anterior cingulate gyrus, left and right posterior cingulate gyrus, left posterior parieto-occipital cortex, and right precuneus) in which TID magnitude varied across task levels within a factor. Follow-up tests indicated that for each of the three factors, TID magnitude increased with task difficulty. These results suggest that TID represents reallocation of processing resources from areas in which TID occurs to areas involved in task performance. Short-term memory load and stimulus rate also predict suppression of spontaneous thought, and many of the brain areas showing TID have been linked with semantic processing, supporting claims that TID may be due in part to suspension of spontaneous semantic processes that occur during "rest" (Binder et al. 1999). The concept that the typical "resting state" is actually a condition characterized by rich cognitive activity has important implications for the design and analysis of neuroimaging studies.
引用
收藏
页码:394 / 408
页数:15
相关论文
共 43 条
[1]  
ANDREASEN NC, 1995, AM J PSYCHIAT, V152, P1576
[2]   INFORMATION THEORY AND STIMULUS-INDEPENDENT THOUGHT [J].
ANTROBUS, JS .
BRITISH JOURNAL OF PSYCHOLOGY, 1968, 59 :423-&
[3]   STUDIES IN STREAM OF CONSCIOUSNESS - EXPERIMENTAL ENHANCEMENT AND SUPPRESSION OF SPONTANEOUS COGNITIVE PROCESSES [J].
ANTROBUS, JS ;
SINGER, JL ;
GREENBER.S .
PERCEPTUAL AND MOTOR SKILLS, 1966, 23 (02) :399-&
[4]   Emotion, decision making and the orbitofrontal cortex [J].
Bechara, A ;
Damasio, H ;
Damasio, AR .
CEREBRAL CORTEX, 2000, 10 (03) :295-307
[5]  
Binder J., 2001, Handbook of Functional Neuroimaging of Cognition, P187
[6]   Conceptual processing during the conscious resting state: A functional MRI study [J].
Binder, JR ;
Frost, JA ;
Hammeke, TA ;
Bellgowan, PSF ;
Rao, SM ;
Cox, RW .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1999, 11 (01) :80-93
[7]   Regional cerebral blood flow during object naming and word reading [J].
Bookheimer, SY ;
Zeffiro, IA ;
Blaxton, T ;
Gaillard, W ;
Theodore, W .
HUMAN BRAIN MAPPING, 1995, 3 (02) :93-106
[8]   Imaging cognition II: An empirical review of 275 PET and fMRI studies [J].
Cabeza, R ;
Nyberg, L .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2000, 12 (01) :1-47
[9]   AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages [J].
Cox, RW .
COMPUTERS AND BIOMEDICAL RESEARCH, 1996, 29 (03) :162-173
[10]  
COX RW, 1996, FMRI2DAY 2 DAY WORKS, P25