Dendritic computation of direction selectivity by retinal ganglion cells

被引:144
作者
Taylor, WR [1 ]
He, SG
Levick, WR
Vaney, DI
机构
[1] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
[2] Australian Natl Univ, Ctr Visual Sci, Canberra, ACT 2601, Australia
[3] Australian Natl Univ, Dept Psychol, Canberra, ACT 2601, Australia
[4] Univ Queensland, Sch Biomed Sci, Vis Touch & Hearing Res Ctr, Brisbane, Qld 4072, Australia
关键词
D O I
10.1126/science.289.5488.2347
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Direction-selective ganglion cells (DSGCs) in the retina respond strongly when stimulated by image motion in a preferred direction but are only weakly excited by image motion in the opposite null direction. Such coding represents an early manifestation of complex information processing in the visual system, but the cellular locus and the synaptic mechanisms have yet to be elucidated. We recorded the synaptic activity of DSGCs using strategies to observe the asymmetric inhibitory inputs that underlie the generation of direction selectivity. The critical nonlinear interactions between the excitatory and inhibitory inputs took place postsynaptically within the dendrites of the DSGCs.
引用
收藏
页码:2347 / 2350
页数:4
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