Role of in vivo proton magnetic resonance spectroscopy in the diagnosis and management of brain abscesses

被引:64
作者
Dev, R
Gupta, RK [1 ]
Poptani, H
Roy, R
Sharma, S
Husain, M
机构
[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Radiol, MR Sect, King George Med Coll, Lucknow 226014, Uttar Pradesh, India
[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Neurosurg, MR Sect, King George Med Coll, Lucknow 226014, Uttar Pradesh, India
[3] Reg Sophisticated Instrumentat Ctr, Cent Drug Res Inst, Lucknow, Uttar Pradesh, India
关键词
brain abscess; brain tumor; magnetic resonance spectroscopy;
D O I
10.1097/00006123-199801000-00008
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
OBJECTIVE: In vivo proton magnetic resonance spectroscopy was performed for 24 patients with pyogenic brain abscesses, to examine the consistency of the spectral patterns and to observe the changes in metabolites with treatment. METHODS: Localized proton spectra were obtained from 4- to 8-ml volumes in the abscesses, using stimulated echo acquisition mode and spin echo sequences. Twenty-two patients were treated with combined surgical and medical therapy, and two patients were treated conservatively. High-resolution magnetic resonance spectroscopy was performed for 15 samples of abscesses obtained from these patients, to confirm the assignments of resonances seen in vivo. Postaspiration studies were performed for 12 patients treated with combined medical and surgical therapy and 2 patients treated medically. RESULTS: Lactate and amino acids were seen in spectra for all patients, irrespective of the time of spectroscopy after the onset of combined medical and surgical therapy. Acetate and pyruvate disappeared after 1 week of combined treatment. CONCLUSION: It was concluded that spectral patterns for brain abscesses are consistent and specific and can assist in the noninvasive diagnosis of abscesses. Responses to combined treatment could be monitored by showing the changes in metabolite patterns in serial spectroscopic studies.
引用
收藏
页码:37 / 42
页数:6
相关论文
共 18 条
  • [1] Bhatia R, 1973, Int Surg, V58, P565
  • [2] Bottomley P., 1984, Patent, Patent No. [4480228, 4,480,228]
  • [3] NEUROPATHOLOGICAL AND COMPUTERIZED TOMOGRAPHIC FINDINGS IN EXPERIMENTAL BRAIN-ABSCESS
    BRITT, RH
    ENZMANN, DR
    YEAGER, AS
    [J]. JOURNAL OF NEUROSURGERY, 1981, 55 (04) : 590 - 603
  • [4] LOCALIZED PROTON SPECTROSCOPY USING STIMULATED ECHOES
    FRAHM, J
    MERBOLDT, KD
    HANICKE, W
    [J]. JOURNAL OF MAGNETIC RESONANCE, 1987, 72 (03): : 502 - 508
  • [5] GARTH JM, 1990, PRINCIPLES BACTERIOL, V1, P39
  • [6] TC-99M-HEXAMETHYLPROPYLENEAMINE OXIME LEUKOCYTE SCINTIGRAPHY AND C-REACTIVE PROTEIN-LEVELS IN THE DIFFERENTIAL-DIAGNOSIS OF BRAIN ABSCESSES
    GRIMSTAD, IA
    HIRSCHBERG, H
    ROOTWELT, K
    [J]. JOURNAL OF NEUROSURGERY, 1992, 77 (05) : 732 - 736
  • [7] IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN A CASE OF INTRACRANIAL HYDATID CYST
    KOHLI, A
    GUPTA, RK
    POPTANI, H
    ROY, R
    [J]. NEUROLOGY, 1995, 45 (03) : 562 - 564
  • [8] IMPROVED MANAGEMENT OF MULTIPLE BRAIN ABSCESSES - A COMBINED SURGICAL AND MEDICAL APPROACH
    MAMELAK, AN
    MAMPALAM, TJ
    OBANA, WG
    ROSENBLUM, ML
    [J]. NEUROSURGERY, 1995, 36 (01) : 76 - 85
  • [9] COMPARISON OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES FROM PERIPHERAL-BLOOD AND PURULENT EXUDATES BY HIGH-RESOLUTION H-1 MRS
    MAY, GL
    SZTELMA, K
    SORRELL, TC
    MOUNTFORD, CE
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1991, 19 (01) : 191 - 198
  • [10] MENDZ GL, 1989, J BIOL CHEM, V264, P2100