Lanthanide(III) chelates for NMR biomedical applications

被引:652
作者
Aime, S [1 ]
Botta, M [1 ]
Fasano, M [1 ]
Terreno, E [1 ]
机构
[1] Univ Turin, Dipartimento Chim IFM, I-10125 Turin, Italy
关键词
D O I
10.1039/a827019z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The peculiar magnetic properties of lanthanide(III) ions may be exploited for the development of powerful NMR probes for biomedical applications, Gd-III chelates are in current clinical use as contrast agents for magnetic resonance imaging, Other paramagnetic lanthanide(III) complexes endowed with shift reagent capabilities are used for the separation of NMR resonances of species present in the inner and outer cellular compartments and for the measurement of pH and temperature.
引用
收藏
页码:19 / 29
页数:11
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共 36 条
  • [1] SYNTHESIS AND NMRD STUDIES OF GD3+ COMPLEXES OF MACROCYCLIC POLYAMINO POLYCARBOXYLIC LIGANDS BEARING BETA-BENZYLOXY-ALPHA-PROPIONIC RESIDUES
    AIME, S
    BOTTA, M
    ERMONDI, G
    [J]. INORGANIC CHEMISTRY, 1992, 31 (06) : 1100 - 1103
  • [2] Paramagnetic complexes as novel NMR pH indicators
    Aime, S
    Botta, M
    Milone, L
    Terreno, E
    [J]. CHEMICAL COMMUNICATIONS, 1996, (11) : 1265 - 1266
  • [3] Extent of hydration of octadentate lanthanide complexes incorporating phosphinate donors: Solution relaxometry and luminescence studies
    Aime, S
    Botta, M
    Parker, D
    Williams, JAG
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (01): : 17 - 23
  • [4] A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy
    Aime, S
    Botta, M
    Fasano, M
    Terreno, E
    Kinchesh, P
    Calabi, L
    Paleari, L
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1996, 35 (05) : 648 - 651
  • [5] SOLUTION AND SOLID-STATE CHARACTERIZATION OF HIGHLY RIGID, 8-COORDINATE LANTHANIDE(III) COMPLEXES OF A MACROCYCLIC TETRABENZYLPHOSPHINATE
    AIME, S
    BATSANOV, AS
    BOTTA, M
    HOWARD, JAK
    PARKER, D
    SENANAYAKE, K
    WILLIAMS, JAG
    [J]. INORGANIC CHEMISTRY, 1994, 33 (21) : 4696 - 4706
  • [6] Prototropic vs whole water exchange contributions to the solvent relaxation enhancement in the aqueous solution of a cationic Gd3+ macrocyclic complex
    Aime, S
    Barge, A
    Botta, M
    Parker, D
    DeSousa, AS
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (20) : 4767 - 4768
  • [7] SYNTHESIS AND CHARACTERIZATION OF A NOVEL DTPA-LIKE GADOLINIUM(III) COMPLEX - A POTENTIAL REAGENT FOR THE DETERMINATION OF GLYCATED PROTEINS BY WATER PROTON NMR RELAXATION MEASUREMENTS
    AIME, S
    BOTTA, M
    DASTRU, W
    FASANO, M
    PANERO, M
    ARNELLI, A
    [J]. INORGANIC CHEMISTRY, 1993, 32 (10) : 2068 - 2071
  • [8] Conformational and coordination equilibria on DOTA complexes of lanthanide metal ions in aqueous solution studied by H-1-NMR spectroscopy
    Aime, S
    Botta, M
    Fasano, M
    Marques, MPM
    Geraldes, CFGC
    Pubanz, D
    Merbach, AE
    [J]. INORGANIC CHEMISTRY, 1997, 36 (10) : 2059 - 2068
  • [9] NMR EVIDENCE OF A LONG EXCHANGE LIFETIME FOR THE COORDINATED WATER IN LN(III)-BIS(METHYL AMIDE)-DTPA COMPLEXES (LN=GD, DY)
    AIME, S
    BOTTA, M
    FASANO, M
    PAOLETTI, S
    ANELLI, PL
    UGGERI, F
    VIRTUANI, M
    [J]. INORGANIC CHEMISTRY, 1994, 33 (21) : 4707 - 4711
  • [10] Gd(III) complexes as contrast agents for magnetic resonance imaging: A proton relaxation enhancement study of the interaction with human serum albumin
    Aime, S
    Botta, M
    Fasano, M
    Crich, SG
    Terreno, E
    [J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 1996, 1 (04): : 312 - 319