EGF-receptor regulates salivary gland branching morphogenesis by supporting proliferation and maturation of epithelial cells and survival of mesenchymal cells

被引：37

作者：

Haara, Otso ^{[1
]}

Koivisto, Tarja ^{[1
]}

Miettinen, Paivi J. ^{[1
,2
]}

机构：

[1] Univ Helsinki, Pediat Res Unit, HUCH Hosp Children & Adolescents, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Hosp Children & Adolescents, FIN-00014 Helsinki, Finland

来源：

DIFFERENTIATION | 2009年 / 77卷 / 03期

关键词：

EGF receptor; Transgenic mouse; Salivary gland; Branching morphogenesis; Apoptosis; Gefitinib; MMP2; Plasminogen activator; EPIDERMAL-GROWTH-FACTOR; MOUSE SUBMANDIBULAR-GLAND; MICE LACKING EGF; MAMMARY-GLAND; PLASMINOGEN-ACTIVATOR; ERBB RECEPTORS; TGF-ALPHA; IN-VITRO; EXPRESSION; AMPHIREGULIN;

D O I：

10.1016/j.diff.2008.10.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Epidermal growth factor receptor (EGF-R) regulates epithelial morphogenesis during development and is important for the proper branching of the lung, mammary gland, and pancreas. We analyzed the salivary gland phenotype of EGF-R-deficient mice and showed impaired growth, branching, and maturation of the epithelium. Furthermore, treatment of wild-type E13 salivary glands with gefitinib, a small molecular inhibitor of EGF-R, led to apoptosis of the mesenchyme. Interestingly, MMP2 and plasminogen activators were upregulated upon inhibition of EGF-R signaling. To summarize, we show that EGF-R is a physiological regulator of salivary gland development and its main function is to support the proliferation and maturation of the epithelium and the survival of the mesenchyme. (C) 2008 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.

引用

页码：298 / 306

页数：9

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