Olfactory processing and behavior downstream from highly selective receptor neurons

被引:112
作者
Schlief, Michelle L. [1 ]
Wilson, Rachel I. [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
关键词
D O I
10.1038/nn1881
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In both the vertebrate nose and the insect antenna, most olfactory receptor neurons ( ORNs) respond to multiple odors. However, some ORNs respond to just a single odor, or at most to a few highly related odors. It has been hypothesized that narrowly tuned ORNs project to narrowly tuned neurons in the brain, and that these dedicated circuits mediate innate behavioral responses to a particular ligand. Here we have investigated neural activity and behavior downstream from two narrowly tuned ORN types in Drosophila melanogaster. We found that genetically ablating either of these ORN types impairs innate behavioral attraction to their cognate ligand. Neurons in the antennal lobe postsynaptic to one of these ORN types are, like their presynaptic ORNs, narrowly tuned to a pheromone. However, neurons postsynaptic to the second ORN type are broadly tuned. These results demonstrate that some narrowly tuned ORNs project to dedicated central circuits, ensuring a tight connection between stimulus and behavior, whereas others project to central neurons that participate in the ensemble representations of many odors.
引用
收藏
页码:623 / 630
页数:8
相关论文
共 49 条
[1]   CENTRAL PROCESSING OF SEX-PHEROMONE, HOST ODOR, AND OVIPOSITION DETERRENT INFORMATION BY INTERNEURONS IN THE ANTENNAL LOBE OF FEMALE SPODOPTERA-LITTORALIS (LEPIDOPTERA, NOCTUIDAE) [J].
ANTON, S ;
HANSSON, BS .
JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 350 (02) :199-214
[2]   CIS-VACCENYL ACETATE AS AN AGGREGATION PHEROMONE IN DROSOPHILA-MELANOGASTER [J].
BARTELT, RJ ;
SCHANER, AM ;
JACKSON, LL .
JOURNAL OF CHEMICAL ECOLOGY, 1985, 11 (12) :1747-1756
[3]   Is the vomeronasal system really specialized for detecting pheromones? [J].
Baxi, KN ;
Dorries, KM ;
Eisthen, HL .
TRENDS IN NEUROSCIENCES, 2006, 29 (01) :1-7
[4]   INSECT OLFACTORY RECEPTORS [J].
BOECKH, J ;
KAISSLING, KE ;
SCHNEIDER, D .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1965, 30 :263-+
[5]   THRESHOLD AND ODOR SPECIFICITY OF PHEROMONE-SENSITIVE NEURONS IN THE DEUTOCEREBRUM OF ANTHERAEA-PERNYI AND ANTHERAEA-POLYPHEMUS (SATURNIDAE) [J].
BOECKH, J ;
BOECKH, V .
JOURNAL OF COMPARATIVE PHYSIOLOGY, 1979, 132 (03) :235-242
[6]   Pheromonal and host-odor processing in the insect antennal lobe: how different? [J].
Christensen, TA ;
Hildebrand, JG .
CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (04) :393-399
[7]  
CHRISTENSEN TA, 1991, J COMP PHYSIOL A, V169, P259
[8]  
Clyne Peter, 1997, Invertebrate Neuroscience, V3, P127, DOI 10.1007/BF02480367
[9]   Molecular, anatomical, and functional organization of the Drosophila olfactory system [J].
Couto, A ;
Alenius, M ;
Dickson, BJ .
CURRENT BIOLOGY, 2005, 15 (17) :1535-1547
[10]  
de Bruyne M, 1999, J NEUROSCI, V19, P4520