Synthesis and regioselective alkylation of 1,6-and 1,7-naphthyridines

被引：28

作者：

Colandrea, VJ ^{[1
]}

Naylor, EM ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)01400-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A regioselective alkylation of naphthyridines 4a-d, through the action of ethylchloroformate and benzylstannane 5, afforded the benzyl substituted dihydronaphthyridines 3a-d. These key intermediates 3a-d were transformed into the desired targets 2a-d in seven steps. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：8053 / 8057

页数：5

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