Pseudo-A(1,3) strain as a key conformational control element in the design of poly-L-proline type II peptide mimics

被引：47

作者：

Zhang, R ^{[1
]}

Brownewell, F ^{[1
]}

Madalengoitia, JS ^{[1
]}

机构：

[1] Univ Vermont, Dept Chem, Burlington, VT 05405 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 16期

关键词：

D O I：

10.1021/ja972494e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy for the synthesis of peptide mimics of the poly-L-proline type II secondary structure from 4-substituted prolines is presented. Dimeric and trimeric oligomers composed of 3-substituted prolines are shown by NMR to preferentially populate the poly-L-proline type II secondary structure in both CDCl3 and D2O. Oligomers composed of 4-substituted prolines thus imitate the desired backbone conformation and are able to incorporate non-prolyl side chains on the proline backbone.

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页码：3894 / 3902

页数：9

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