Evidence of an inverted hexagonal phase in self-assembled phospholipid-DNA-metal complexes

被引：43

作者：

Francescangeli, O

Pisani, M

Stanic, V

Bruni, P

Weiss, TM

机构：

[1] Univ Politecn Marche, Dipartimento Fis & Ingn Mat & Terr, I-60131 Ancona, Italy

[2] Univ Politecn Marche, INFM, I-60131 Ancona, Italy

[3] Univ Ancona, Dipartimento Sci Mat & Terra, I-60131 Ancona, Italy

[4] European Synchrotron Radiat Facil, F-38043 Grenoble, France

来源：

EUROPHYSICS LETTERS | 2004年 / 67卷 / 04期

关键词：

D O I：

10.1209/epl/i2004-10091-y

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We report the first observation of an inverted hexagonal phase of phospholipid-DNA-metal complexes. These ternary complexes are formed in a, self-assembled manner when water solutions of neutral lipid dioleoylphosphatidylethanolamine (DOPE), DNA and divalent metal cations (Me2+; Me = Fe, Co, Mg, Mn) are mixed, which represents a striking example of supramolecular chemistry. The structure, derived from synchrotron X-ray diffraction, consists of cylindrical DNA strands coated by neutral lipid monolayers and arranged on a two-dimensional hexagonal lattice (H-11(c)). Besides the fundamental aspects, DOPE-DNA-Me2+ complexes may be of great interest as efficient nonviral delivery systems in gene therapy applications because of the low inherent cytotoxicity and the potential high transfection efficiency.

引用

页码：669 / 675

页数：7

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