A convergent total synthesis of phorboxazole A

被引：62

作者：

González, MA ^{[1
]}

Pattenden, G ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 11期

关键词：

antifungal agents; antitumor agents; natural products; olefination; total synthesis;

D O I：

10.1002/anie.200390321

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The potent cytostatic marine metabolite phorboxazole A (see structure) was prepared from three key fragments. Following attachment of a major portion of the side chain through C32-C33 and an intermolecular E-selective olefination reaction to form the C19-C20 double bond, the C2-C3 double bond was put in place through an intramolecular Z-selective olefination reaction, with formation of the macrolide.

引用

页码：1255 / 1258

页数：4

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