Stimulatory effect of bradykinin (BK) on glucagon secretion from the perfused rat pancreas:: Involvement of BK2 receptors

被引：5

作者：

Abu-Basha, EA ^{[1
]}

Makowski, JP ^{[1
]}

Yibchok-anun, S ^{[1
]}

Hsu, WH ^{[1
]}

机构：

[1] Iowa State Univ, Dept Biomed Sci, Ames, IA 50011 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2000年 / 49卷 / 10期

关键词：

D O I：

10.1053/meta.2000.9511

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of the study is to investigate the direct effect of bradykinin (BK), a potent vasoactive nonapeptide, on glucagon secretion from the perfused rat pancreas. BK (0.1, 1, and 10 mu mol/L) increased glucagon secretion in a concentration-dependent manner. HOE 140, a BK2 receptor antagonist (0.01, 0.1, and 1 nmol/L), prevented the stimulatory effect of BK on glucagon secretion in a concentration-dependent manner. In contrast, des-Arg(9),Leu(8)-BK, a BK1 receptor antagonist (1 nmol/L), failed to antagonize the effect of BK. Thus, BK stimulates glucagon secretion from the perfused rat pancreas by activating BK2 receptors, but not BK1 receptors. Copyright (C) 2000 by W.B. Saunders Company.

引用

页码：1370 / 1373

页数：4

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