Different PS application methods for laserlight induced fluorescence diagnostics (LIFD) of dysplasia and early cancer of the colon

被引：1

作者：

Gahlen, J ^{[1
]}

Pressmar, J ^{[1
]}

Stern, J ^{[1
]}

Bohm, J ^{[1
]}

Sinn, HJ ^{[1
]}

Born, IA ^{[1
]}

Holle, R ^{[1
]}

Herfarth, C ^{[1
]}

机构：

[1] Univ Heidelberg, Chirurg Klin, D-69120 Heidelberg, Germany

来源：

MEDICAL APPLICATIONS OF LASERS IN DERMATOLOGY, OPHTHALMOLOGY, DENTISTRY, AND ENDOSCOPY, PROCEEDINGS OF | 1997年 / 3192卷

关键词：

colon carcinoma; fluorescence diagnostics; endoscopy; ulcerative colitis; LIFD; ALA; Photofrin; mTHPC;

D O I：

10.1117/12.297849

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Conventional diagnostics fail to trace dysplasias and early cancers of the colon. By means of Laserlight Induced Fluorescence Diagnostics (LIFD) macroscopically not visible malignant tumors and dysplasias of the colon can be detected. The main side effect of systemically applicated photosensitisers is a general photosensibilisation of the: organism which provokes an increased photosensitivity of the body. Local application of delta-aminolevulinic acid (ALA) reduces systemic uptake without impairment of the quality of investigation. Colorectal cancer in male wistar rats was induced by weekly subcutanious (s.c.) injections of 1,2-dimethylhydrazine (DMH) for 17 weeks. After s.c. DMH injection the wistar rats (n=25) developed in average 5.6 macroscopically visible colon carcinomas. 80% of these tumors were detected by LIFD after photosensibilisation with Photofrin II intravenously (i.v.), 29% after application of mTHPC (i.v.), 13% after ALA (i.v.), 20% after intraperitoneal application of ALA (i.p.) and 57% after local application of ALA in the colon. LIFD is a capable method for the detection of macroscopically not visible dysplasias and colon carcinomas of the rat induced by DMH. The applied PS and the method of application influences the detection of carcinomas and dysplasias. Systemic photosensibilisation of the whole organism can be avoided by the local application of ALA without limiting the quality of investigation.

引用

页码：263 / 268

页数：6