Antimicrobial and antileishmanial activities of hypocrellins A and B

被引：131

作者：

Ma, GY

Khan, SI

Jacob, MR

Tekwani, BL

Li, ZQ

Pasco, DS

Walker, LA

Khan, LA ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA

[4] Yunnan Univ, Expt Ctr, Kunming, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 11期

关键词：

D O I：

10.1128/AAC.48.11.4450-4452.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.

引用

页码：4450 / 4452

页数：3

共 21 条

[1]

Ali SM, 2002, INT J MOL MED, V9, P461

[2]

Bao JN., 1985, ACTA ACAD MED SIN, V7, P349

[3]

Cao E H, 1988, Shi Yan Sheng Wu Xue Bao, V21, P79

[4]

Chen, 1981, KEXUE TONGBAO, V26, P1040