Reduction of β-hydroxyketones by Sml2/H2O/Et3N

被引：41

作者：

Davis, TA ^{[1
]}

Chopade, PR

Hilmersson, G

Flowers, RA

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

[2] Univ Gothenburg, Dept Chem, SE-41296 Gothenburg, Sweden

[3] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 01期

关键词：

D O I：

10.1021/ol047835p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reduction of a series of beta-hydroxyketones by SmI2/H2O/Et3N provided 1,3-diols in quantitative yields. The reactions were exceedingly clean with no byproduct formation, negating the need for further purification. Most reactions provided moderate to excellent diastereoselectivity with syn-diols as the major isomer in most instances.

引用

页码：119 / 122

页数：4

共 19 条

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