Tumor microenvironment: The role of the tumor stroma in cancer

被引：636

作者：

Li, Hanchen ^{[1
]}

Fan, Xueli ^{[1
]}

Houghton, JeanMarie ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med & Canc Biol, Div Gastroenterol, Worcester, MA 01605 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2007年 / 101卷 / 04期

关键词：

tumor microenvironment; tumor stroma; cancer-associated fibroblasts; neovascularization; tumor-associated inflammation; bone marrow-derived stem cells; mesenchymal stem cells;

D O I：

10.1002/jcb.21159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The tumor microenvironment, composed of non-cancer cells and their stroma, has become recognized as a major factor influencing the growth of cancer. The microenvironment has been implicated in the regulation of cell growth, determining metastatic potential and possibly determining location of metastatic disease, and impacting the outcome of therapy. While the stromal cells are not malignant per se, their role in supporting cancer growth is so vital to the survival of the tumor that they have become an attractive target for chemotherapeutic agents. In this review, we will discuss the various cellular and molecular components of the stromal environment, their effects on cancer cell dynamics, and the rationale and implications of targeting this environment for control of cancer. Additionally, we will emphasize the role of the bone marrow-derived cell in providing cells for the stroma.

引用

页码：805 / 815

页数：11

共 61 条

[1]

Skin carcinoma arising from donor cells in a kidney transplant recipient [J].

Aractingi, S ;

Kanitakis, J ;

Euvrard, S ;

Le Danff, C ;

Peguillet, I ;

Khosrotehrani, K ;

Lantz, O ;

Carosella, ED .

CANCER RESEARCH, 2005, 65 (05) :1755-1760

[2]

Fibronectin fragments and their role in inflammatory arthritis [J].

Barilla, ML ;

Carsons, SE .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2000, 29 (04) :252-265

[3]

A randomized trial of aspirin to prevent colorectal adenomas [J].

Baron, JA ;

Cole, BF ;

Sandler, RS ;

Haile, RW ;

Ahnen, D ;

Bresalier, R ;

McKeown-Eyssen, G ;

Summers, RW ;

Rothstein, R ;

Burke, CA ;

Snover, DC ;

Church, TR ;

Allen, JI ;

Beach, M ;

Beck, GJ ;

Bond, JH ;

Byers, T ;

Greenberg, ER ;

Mandel, JS ;

Marcon, N ;

Mott, LA ;

Pearson, L ;

Saibil, F ;

van Stolk, RU .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (10) :891-899

[4]

TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia [J].

Bhowmick, NA ;

Chytil, A ;

Plieth, D ;

Gorska, AE ;

Dumont, N ;

Shappell, S ;

Washington, MK ;

Neilson, EG ;

Moses, HL .

SCIENCE, 2004, 303 (5659) :848-851

[5]

Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis [J].

Bindra, RS ;

Glazer, PM .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 569 (1-2) :75-85

[6]

PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells [J].

Boire, A ;

Covic, L ;

Agarwal, A ;

Jacques, S ;

Sherifl, S ;

Kuliopulos, A .

CELL, 2005, 120 (03) :303-313

[7]

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment [J].

Burger, JA ;

Kipps, TJ .

BLOOD, 2006, 107 (05) :1761-1767

[8]

VEGF as a key mediator of angiogenesis in cancer [J].

Carmeliet, P .

ONCOLOGY, 2005, 69 :4-10

[9]

Castelao JE, 2000, BRIT J CANCER, V82, P1364

[10]

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 [J].

Ceradini, DJ ;

Kulkarni, AR ;

Callaghan, MJ ;

Tepper, OM ;

Bastidas, N ;

Kleinman, ME ;

Capla, JM ;

Galiano, RD ;

Levine, JP ;

Gurtner, GC .

NATURE MEDICINE, 2004, 10 (08) :858-864

← 1 2 3 4 5 6 7 →