Endogenous GLP-1 is involved in β-amyloid protein-induced memory impairment and hippocampal neuronal death in rats

被引：38

作者：

Oka, JI ^{[1
]}

Suzuki, E ^{[1
]}

Kondo, Y ^{[1
]}

机构：

[1] Meijo Univ, Fac Pharmaceut Sci, Dept Chem Pharmacol, Nagoya, Aichi 4688503, Japan

来源：

BRAIN RESEARCH | 2000年 / 878卷 / 1-2期

关键词：

beta-amyloid protein; apoptosis; exendin (5-39); glucagon-like peptide-1; hippocampus; memory;

D O I：

10.1016/S0006-8993(00)02741-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effects of continuous infusion of exendin (5-39), an antagonist of glucagon-like peptide-1 (GLP-1) receptors, into the rat brain using a mini-osmotic pump on beta-amyloid protein-induced amnesia and apoptosis. Co-infusion of exendin (5-39) with beta-amyloid protein (1-40) prevented the memory impairment and DNA fragmentation in the hippocampal CA1 region observed with infusion of beta-amyloid protein alone. These results indicated a functional role of endogenous GLP-1 in beta-amyloid protein-induced neurotoxicity. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：194 / 198

页数：5

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