Role of the brain heme oxygenase-carbon monoxide pathway in stress fever in rats

被引：17

作者：

Steiner, AA ^{[1
]}

Reste, G

Branco, LGS

机构：

[1] Med Sch Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP, Brazil

[2] St Joseph Hosp & Med Ctr, Phoenix, AZ USA

[3] Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, Ribeirao Preto, SP, Brazil

来源：

NEUROSCIENCE LETTERS | 2003年 / 341卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

body temperature; hyperthermia; anxiety; restraint; central nervous system; metaloporphyrins;

D O I：

10.1016/S0304-3940(03)00197-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study was aimed at testing the hypothesis that the brain heme oxygenase (HO)-carbon monoxide (CO) pathway plays a role in stress fever. To this end, the effect of the HO inhibitor, zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG), on restraint-induced fever was tested. Intracerebroventricular ZnDPBG (200 nmol) did not affect the body core temperature of unrestrained rats, but markedly attenuated restraint-induced fever. However, at the same dose, intraperitoneal ZnDPBG did not affect the febrile response to restraint. Taken together, these results indicate that the brain HO-CO pathway plays a major role in the genesis of stress fever in rats. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 196

页数：4

共 37 条

[1] Role of the haem oxygenase-carbon monoxide pathway in insulin-induced hypothermia: evidence for carbon monoxide involvement [J].

Almeida, MC ;

Branco, LGS .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2002, 444 (1-2) :244-250

[2] Inhibition of the central heme oxygenase-carbon monoxide pathway increases 2-deoxy-D-glucose-induced hypothermia in rats [J].

Almeida, MC ;

Branco, LGS .

NEUROSCIENCE LETTERS, 2000, 290 (01) :45-48

[3]

ANDERSON KE, 1984, J PHARMACOL EXP THER, V228, P327

[4]

Appleton SD, 1999, DRUG METAB DISPOS, V27, P1214

[5] Role of the preoptic-anterior hypothalamus in thermoregulation and fever [J].

Boulant, JA .

CLINICAL INFECTIOUS DISEASES, 2000, 31 :S157-S161

[6] Tissue distribution of synthetic heme analogues: Studies with tin, chromium, and zinc mesoporphyrins [J].

Bundock, EA ;

Drummond, GS ;

Kappas, A .

PHARMACOLOGY, 1996, 52 (03) :187-198

[7] Emotional fever in rats persists after vagotomy [J].

Cabanac, M ;

Dardashti, M .

PHYSIOLOGY & BEHAVIOR, 1999, 67 (03) :347-350

[8] A CRITICAL ROLE FOR CENTRAL VASOPRESSIN IN REGULATION OF FEVER DURING BACTERIAL-INFECTION [J].

CRIDLAND, RA ;

KASTING, NW .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (06) :R1235-R1240

[9] The nitric oxide pathway is an important modulator of stress-induced fever in rats [J].

De Paula, D ;

Steiner, AA ;

Branco, LGS .

PHYSIOLOGY & BEHAVIOR, 2000, 70 (05) :505-511

[10] Carbon monoxide as a novel central pyrogenic mediator [J].

Jang, CG ;

Lee, SJ ;

Yang, SI ;

Kim, JH ;

Sohn, UD ;

Lee, SY .

ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (03) :343-348

← 1 2 3 4 →