Cholinesterase reactivators derived from pyridine-2-carbaldoxime

被引：13

作者：

Bielavsky, J ^{[1
]}

Kassa, J

Elsnerova, I

Dejmek, L

机构：

[1] JE Purkyne Mil Med Acad, Hradec Kralove 50001, Czech Republic

[2] Res Inst Pharm & Biochem, Prague 13060 3, Czech Republic

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1998年 / 63卷 / 02期

关键词：

reactivators; cholinesterase; pyridines; pyridinium salts; organophosphates;

D O I：

10.1135/cccc19980199

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monoquaternary reactivators of cholinesterase 3a-3e were prepared by quaternization of substituted pyridine-2-carbaldoximes with an ester (1a, 1b) or carbamoyl (2) function in position 4. A new bis-quaternary reactivator, 4-carbamoyl-2'-[(hydroxyimino)methyl]-1, 1'-(but-2-ene-1,4-diyl)bispyridinium salt (5), was derived from the unsubstituted pyridine-2-carbaldoxime. The compounds were characterized by UV spectra and ionization constants. The substances exhibit antidote effects in intoxications with organophosphate cholinesterase inhibitors.

引用

页码：199 / 204

页数：6

共 7 条

[1] REVIEW OF OXIMES AVAILABLE FOR TREATMENT OF NERVE AGENT POISONING [J].

DAWSON, RM .

JOURNAL OF APPLIED TOXICOLOGY, 1994, 14 (05) :317-331

[2]

HAGEDORN I, 1977, Patent No. 2616481

[3] SYNTHESIS OF OXIMES .3. IODINE-DIMETHYL SULFOXIDE REACTION WITH METHYLPYRIDINES [J].

MARKOVAC, A ;

STEVENS, CL ;

ASH, AB ;

HACKLEY, BE .

JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (03) :841-&

[4]

MUNIER R, 1951, B SOC CHIM BIOL, V33, P846

[5] REACTIVATING EFFECT OF ALPHA,OMEGA-BIS-(4-PYRIDINEALDOXIME)-2-TRANS-BUTENE DIBROMIDE ON ISOPROPYL-METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE [J].

PATOCKA, J ;

BIELAVSKY, J ;

ORNST, F .

FEBS LETTERS, 1970, 10 (03) :182-+

[6]

QUEGUINER G, 1969, B SOC CHIM FR, P3678

[7] 2-CARBALDOXIMES OF PYRIDINE-4-CARBOXYLIC AND PYRIDINE-5-CARBOXYLIC ACIDS [J].

REYESRIVERA, HM ;

HUTCHINS, RO ;

DALTON, DR .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (02) :665-669

← 1 →