Pharmacotherapy and osteoarthritis

被引：10

作者：

Brady, SJ ^{[1
]}

Brooks, P

Conaghan, P

Kenyon, LM

机构：

[1] St Vincents Hosp, Dept Rheumatol, Darlinghurst, NSW 2010, Australia

[2] St Vincents Hosp, Med Professorial Unit, Darlinghurst, NSW 2010, Australia

来源：

BAILLIERES CLINICAL RHEUMATOLOGY | 1997年 / 11卷 / 04期

关键词：

osteoarthritis; management; pharmacotherapy;

D O I：

10.1016/S0950-3579(97)80008-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Therapy for osteoarthritis (OA) is aimed at relieving symptoms and at maximizing function. Therapies can be considered as either symptom modifying OA drugs (SMOADs) or as disease modifying OA drugs (DMOADs). Currently available agents fall into the category of SMOADs. Analgesic medications, particularly paracetamol and capsaicin, have proven efficacy in OA and are recommended first line therapies. Non-steroidal anti-inflammatory drugs (NSAIDs) do appear to provide extra symptomatic benefit for some patients but have greater toxicity. Newer generation NSAIDs may have safety advantages which remain to be confirmed in practice. Further therapies are being developed which aim to prevent cartilage damage and/or aid cartilage restoration, but these DMOADs remain in the experimental stage.

引用

页码：749 / 768

页数：20

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