Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress

被引：224

作者：

Attard, GS ^{[1
]}

Templer, RH

Smith, WS

Hunt, AN

Jackowski, S

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Univ Southampton, Dept Child Hlth, Southampton SO17 1BJ, Hants, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[4] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA

[5] Univ Tennessee, Dept Biochem, Memphis, TN 38163 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 16期

关键词：

D O I：

10.1073/pnas.160260697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The activity of CTP:phosphocholine cytidylyltransferase, a rate-limiting enzyme in phosphatidylcholine biosynthesis, is modulated by its interaction with lipid bilayers [Kent, C. (1997) Biochim, Biophys, Acta 1348, 79-90]. Its regulation is of central importance in the maintenance of membrane lipid homeostasis, Here we show evidence that the stored curvature elastic stress in the lipid membrane's monolayer modulates the activity of CTP:phosphocholine cytidylyltransferase. Our results show how a purely physical feedback signal could play a key role in the control of membrane lipid synthesis.

引用

页码：9032 / 9036

页数：5

共 40 条

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