Clinical course of patients with major histocompatibility complex class II deficiency

被引：50

作者：

Saleem, MA

Arkwright, PD

Davies, EG

Cant, AJ

Veys, PA

机构：

[1] Hosp Sick Children, London WC1N 3JH, England

[2] Newcastle Gen Hosp, No Supra Reg Bone Marrow Transplant Unit SCID & R, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2000年 / 83卷 / 04期

关键词：

bone marrow transplantation; MHC II deficiency; viral infections; outcome;

D O I：

10.1136/adc.83.4.356

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The clinical course of 10 children who have been diagnosed with major histocompatibility complex (MHC) class II deficiency (bare lymphocyte syndrome) in the UK over the past eight years is described. They have had a generally poor prognosis, with only two of the 10 still alive despite eight attempts at bone marrow transplantation in six patients. Overwhelming viral infection was the predominant cause of death. Alternative transplant strategies or novel therapies are required for these patients.

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收藏

页码：356 / 359

页数：4

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